http://lowdose.energy.gov/ DOE Low Dose Radiation Research Program en-us Wed, 11 May 2011 08:00:00 EST Wed, 11 May 2011 08:00:00 EST http://lowdose.energy.gov/rss/rss.xml Christine.Sharp@pnnl.gov (Christine Sharp) http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/tumor_protein_induced.aspx Translationally Controlled Tumor Protein Induced by Low-Dose Radiation Protects Against DNA Damage In research published online in the Proceedings of the National Academies of Science, scientists at the University of Medicine and Dentistry of New Jersey and the Fourth Military Medical University in the People's Republic of China described an important role of a multifunctional protein in response to low dose radiation-induced DNA damage. http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/ <p>Radiation Biology: Slaying Dragons or Jousting Windmills</br> Keynote Speaker: Dr. Antone Brooks</p> The annual <a href="http://www.nei.org/newsandevents/conferencesandmeetings/rp">NEI Radiation Protection Forum</a> (formerly Health Physics Forum) provides a unique opportunity for nuclear power plant and nuclear fuel cycle radiation protection managers (RPMs) and senior health physics staff to discuss regulatory developments; get updates on industry activities; and share operating experience, lessons learned and best practices. The forum also will include regional RPM meetings. http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/ A recent news article in Nature highlights work being done on archived data and materials from radiation studies performed between 1952 and 1992, and its relevance to questions being addressed by DOE's Low Dose Radiation Research Program. The article, "<a href="http://www.nature.com/news/radiation-risks-raiders-of-the-lost-archive-1.10599">Radiation risks: Raiders of the lost archive</a>," features quotes from Low Dose Program researcher Dr. Gayle Woloschak, a radiation biologist at Northwestern University in Chicago, Illinois, whose laboratory hosts radiobiology archives containing data and tissues from radiobiology mega studies conducted in the second half of the 20th century. http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/ In studies on a human skin tissue model, researchers at Pacific Northwest National Laboratory used a systems biology approach to show that an <a href="http://www.pnl.gov/science/highlights/highlight.asp?id=1156">ionizing radiation dose mimicking that received during a CT scan is sufficient to alter genes in two cell layers.</a> The epidermis is the outer skin layer, and the dermis is beneath it. The researchers found 1452 genes altered in the dermis and 428 genes altered in the epidermis. Genes altered in the two layers showed little overlap, but the affected signaling pathways were similar. http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/ How better to find out what effect ionizing radiation has on human skin than by using the real thing? Researchers at Pacific Northwest National Laboratory did that by performing a <a href="http://www.pnl.gov/science/highlights/highlight.asp?id=1155">quantitative mass spectrometry study on a reconstituted human skin tissue model</a> to identify areas affected by ionizing radiation exposure. Their results suggest that even very low doses of ionizing radiation activate cell-signaling pathways, resulting in altered protein phosphorylation and possibly altered protein function. http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/ The annual Low Dose Radiation Research Program Investigators' Workshop typically held in April or May has been postponed until next year. Please keep checking the website for updates. http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/ <p>Dr. Lynn Hlatky, DOE Low Dose researcher and Director of the Center of Cancer Systems Biology at St. Elizabeth's Medical Center/Tufts University School of Medicine in Boston, MA, has been selected by the International Dose-Response Society as this year's recipient of the Outstanding Leadership Award in the field of dose response. This annual award of excellence recognizes a scientist who has "contributed to a deeper understanding of the relationships between dose and response." </p> <p>Created in 2005, the International Dose-Response Society is dedicated to the study of dose-response in the low dose zone. Dr. Hlatky's award will be presented at the upcoming 11th Annual International Conference: "Dose-Response: Implications for Toxicology, Medicine, and Risk Assessment" in April 2012 in Amherst, MA.</p> http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/program_updates.aspx 36th Lauriston S. Taylor Lecture: NCRP 48th Annual Meeting - Link: <a href="http://www.ncrponline.org/">National Council on Radiation Protection and Measurements</a> http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/links/organizations_conducting_research.aspx The laboratory work for this collaborative study was carried out by Mr. Nielsen with the assistance of Dr. Xihai Wang, a visiting researcher. Both Mr. Nielsen and Dr. Wang were employed by the Pacific Northwest National Laboratory (PNNL), Richland, WA, and members of Dr. Bill Morgan's Radiation Biology and Biophysics research team. PNNL provided Mr. Nielsen's and Dr. Wang's labor and all necessary equipment and supplies. USTUR provided laboratory space. Mr. Nielsen's graduate committee chair was Dr. Allan S. Felsot. - Link: <a href="http://www.ustur.wsu.edu/GraduateProjects/WSU/NielsenMS.html">Washington State University: Graduate Research Collaboration with Pacific Northwest National Laboratory </a> http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/about_meetings_calendar.aspx Annual Conference: Dose Response 2012 - University of Massachusetts, Amherst MA, April 24-25 - Link: <a href="http://www.dose-response.org/">International Dose-Response Society</a> http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/search_pubs.aspx Search by year, keyword, source, author, publication type. We welcome updates to the Low Dose Radiation Research Program. Please submit your event, enter your question, request information to the Low Dose Radiation Research Inquiry/Request Mailbox. Research Inquiry Mailbox: <a href="mailto:lowdose@pnl.gov?cc=julie.wiley@pnl.gov">Mailbox</a> http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/rta.aspx Low Dose program-supported scientists at The University of Chicago have gained more insight into adaptive protective responses indicating the role of oxidative stress, the role of reactive oxygen species (ROS), and the induction of SOD2 (manganese Superoxide Dismutase) activity. These changes are central to the production of adaptive protective responses. http://www.pnnl.gov/contacts/staffinfo.asp?uid=E009110B475D5347B792D99FFD190484 http://lowdose.energy.gov/imagegallery.aspx These are images, photographs, and charts presented or developed for Low Dose Radiation Research Investigators' Meetings. They may be used for presentations or reports. To save, right click on the picture, then choose "Save picture as." Link: http://lowdose.energy.gov/imagegallery.aspx