| Principal Investigator |
Institution |
Project |
| Albrecht, Huguette |
University of California Davis |
Inter-individual variations in the human transcriptome following in vivo exposure to low dose ionizing radiation |
| Alexandrou, Aris |
University of California Davis |
The Circadian Rhythm, A Continuous Transcription-Translation Feedback Loop, Contributes to Low-Dose Radiation-Induced Radioadaptive Response |
| Amundson, Sally |
Columbia University Medical Center |
Low dose and bystander responses in a 3-D human skin model |
| Anderson, Jennifer |
Gray Institute for Radiation Oncology and Biology |
Modulating radiation induced TGFβ and ATM signaling in the DNA damage response |
| Apyar, Umut |
School/Lab |
Epigenetic Alterations in High and Low LET Radiation Induced Genomic Instability |
| Bernal, Autumn |
Duke University Medical Center |
Low-Dose Ionizing Radiation Alters the Epigenome of the Avy Mouse |
| Blakely, E.A. |
Lawrence Berkeley National Laboratory |
A Systems Genetics Approach to Evaluate Serum Cytokine Expression Profiles in 10 cGy-Irradiated Mice: Possible Connection to Susceptibility/Resistance to Cancer |
| Boice, John |
International Epidemiology Institute |
The One Million U.S. Radiation Worker Study |
| Brogan, J.R. |
Colorado State
University |
Mouse Strain-Dependent Variations in Sensitivity to Induction of Gamma-H2AX Foci after Continuous Low Dose-Rate Irradiation: The Atm-/- vs Atm +/+ genotypes on Balb/c, 129S6, C57BL/6J, and A/J inbred strains |
| Candas, Demet |
University of California Davis |
Cell cycle-regulated manganese superoxide dismutase activity via reversible phosphorylation |
| Chen, Wenshu |
Lovelace Respiratory Research Institute |
Biological Basis for Radiation Adaptive Responses that Protect Against Bronchial
Epithelial Cell Transformation |
| Chiolo, Irene |
Lawrence Berkeley National Laboratory |
Chromatin Regulation and Low Dose Irradiation: A Two-Way Street? |
| Coleman, Matthew |
Lawrence Livermore National Laboratory |
Using Co-Regulation to Understand Low-Dose Ionizing Radiation Responsive Genes and
Pathways |
| Cucinotta, Francis |
NASA Johnson Space Center |
Modular Systems Biology applied to TGFbeta and DNA Damage Response Signaling following Low Dose Radiation |
| Ding, Lingling |
Georgia Health Sciences University |
Low dose irradiation of the early vertebrate embryo and early onset of tissue aging |
| Doss, Mohan |
Fox Chase Cancer Center |
Low Dose Radiation Stimulates Antioxidant Capacity in the Brain and Lessens
Behavioral Symptoms in a 6-OHDA-Induced Rat Model of Parkinson's Disease |
| Eldridge, Angela |
University of California Davis |
Profiling of MnSOD Interaction Proteins in Low-Dose Radiation Induced Adaptive Response |
| Fernandez-Garcia, I |
New York University School of Medicine |
Disrupted epithelial morphogenesis and aberrant lineage commitment following radiation and TGFβ |
| Filkowski, Jody |
School/Lab |
Analysis of low dose radiation induced epigenetic modifications in animal and human cell line models |
| Globus, Ruth |
NASA Ames Research Center |
Radiation-induced disruption of skeletal remodeling |
| Gonzales, V |
Lovelace Respiratory Research Institute |
Low-dose, low-LET γ-radiation alters carcinogen-induced splenic cytokine production and immune cell
phenotype of A/J mice |
| Gott, K |
Lovelace Respiratory Research Institute |
Effect of low-dose, low-LET γ-radiation and BaP injection on pulmonary immunity in A/J mice |
| Gross, Louis |
University of Tennessee |
NIMBioS: a National Institute fostering Research and Education at the interface of Mathematics and Biology |
| Hahnfeldt, Philip |
Tufts University School of Medicine |
A Multicellular Basis for the Origination of Blast Crisis in
Chronic Myeloid Leukemia |
| Haley, Benjamin |
Northwestern University |
Control Group Variation in the Janus Studies |
| Huang, G |
Lawrence Berkeley National Laboratory |
An integrated genetics approach to systemic low-dose radiation responses |
| Jaafar, Lahcen |
Georgia Health Sciences University |
Development of stable lines of transgenic zebrafish (Danio rerio) to
investigate genomic instability |
| Jacobus, James |
University of Iowa |
LET and gender are critical factors in accelerating development of lymphoma in
irradiated Bax transgenic C57Bl/6 mice |
| Jin, Cuihong |
University of California Davis |
Cyclin D1 and CDK4 translocate into mitochondria and interact with MnSOD in low dose radiation-induced adaptive radioprotection |
| Kadhim, Munira |
Oxford Brookes University |
Mechanisms underlying cellular responses of cells from haemopoeitic
tissue to low dose-low LET radiation |
| Kleiman, N.J. |
Columbia University |
Low-Dose Radiation Cataract and Genetic Determinants of Radiosensitivity |
| Lall, Rajuli |
The University of Texas Health Science Center at San Antonio |
A role for c-Abl/p53 pathway in radio-adaptive response |
| Li, Henghong |
Georgetown University |
Effects of low-dose radiation on immune cell function using genetic and
metabolomics approaches |
| Li, Wenrong |
University of Colorado School of Medicine |
Quantitative, non-invasive imaging of radiation-induced DNA double strand breaks in vivo |
| Liu, William |
Northwestern University |
Comparing disease expression across species: an examination of radiation and species specific
disease expression in Mus musculus and Peromyscus leucopus |
| Lo, Alvin |
Lawrence Berkeley National Laboratory |
Using ex vivo organ culture models as surrogates to investigate morphological and functional
differences of mammary glands derived from mouse strains that differ in cancer susceptibility to
understand the underlying mechanisms of radiation sensitivity or resistance |
| Lu, Chung-Ling |
University of California Davis |
Mechanism underlying mTOR-associated Protection in Low Dose Radiation-induced Adaptive Response |
| Maeda, Junko |
Colorado State University |
Radioactivities in Solution by Particle Radiation can Increase Sister Chromatid Exchanges |
| McDonald, J. Tyson |
Steward St. Elizabeth’s Medical Center |
Gene expression analysis of human primary prostate epithelial and fibroblast cell cultures to an acute dose of 10cGy |
| Miller, John |
Washington State University Tri-Cities |
Simulation of Electron Beam Irradiation of a Skin Tissue Model |
| Miller, Richard |
The University of Chicago |
Resveratrol Effects on SOD2 |
| Morales, Julio |
University of Texas Southwestern Medical Center |
KUB5/HERA: a dual acting protein that suppresses genomic instability and
promotes DNA repair after low dose IR exposure |
| Morgan, William |
Pacific Northwest National Laboratory |
PNNLs integrated systems biology approach to understanding the effects of exposure to low doses of ionizing radiation
Low Dose Radiation Research Program Website – Highlighting Low Dose
Research |
| Mott, Joni |
Lawrence Berkeley National Laboratory |
Investigation of non-targeted effects of low dose ionizing radiation on the mammary gland
utilizing three-dimensional culture models of mammary cells derived from mouse strains
that differ in susceptibility to tumorigenesis |
| Murley, Jeffrey |
The University of Chicago |
Roles of TNFα Signaling and NFκB in Thiol- and Low Dose Radiation-Induced Adaptive Responses |
| Nagasawa, H |
Colorado State University |
Chromosome- and Chromatid-type Aberrations after Irradiation of Various HRR or
NHEJ Deficient Mutant Chinese Hamster Cells and Their Wild-type Counterparts in
G0/G1 or LateS/G2 Cell Cycle Phases |
| Nelson, Gregory |
Loma Linda University |
Effects of Radiation on Adaptive Immunity: Contact Hypersensitivity Model |
| Neumaier, Teresa |
Helmholtz Zentrum München |
Non-linear DNA damage response to low-dose ionizing radiation suggests
clustering of DNA breaks in normal human cells |
| Northen, T |
Lawrence Berkeley National Laboratory |
A Systems Genetics Approach to Analyze the Metabolic Responses to Low Dose
Radiation |
| Ostroumova, Evgenia |
National Cancer Institute |
Hypothyroidism prevalence following exposure to radioiodines in childhood and adolescence: Belarusian-American Cohort Study of Thyroid Cancer and Other Thyroid Diseases after the Chernobyl Accident |
| Paunesku, Tatjana |
Northwestern University |
Long term effects of radiation treatments on micro RNAs in mice |
| Raha, Sumita |
Northwestern University |
Alterations in mitochondrial gene copy numbers following irradiation in
radiosensitive mice |
| Richards, Hunter |
Lawrence Berkeley National Laboratory |
Impact of Low-Dose Ionizing Irradiation on Histone Modification and
Chromatin Organization |
| Rydberg, Bjorn |
Lawrence Berkeley National Laboratory |
A Critical Examination of the Adaptive Response for Cytogenetic Damage
in Human Cells, and Insights into the Adaptive Response Mechanism |
| Scott, Bobby |
Lovelace Respiratory Research Institute |
Differential Molecular Changes in the Lung after Low and High Carcinogen Doses and
Implications for Designing Molecular Epidemiology and other Studies of Radiation-Induced
Lung Cancer |
| Smilenov, L |
Columbia University |
miRNA as Bystander Effect Factor |
| Snijders, Antoine |
Lawrence Berkeley National Laboratory |
Genetic susceptibility to low-dose ionizing radiation in the mouse mammary gland
as a means of understanding human risk for breast cancer |
| Song, Ihn-Young |
University of California |
Sequential mutations in Notch1, Fbxw7 and p53 in radiation-induced mouse
thymic lymphomas |
| Sowa, Marianne |
Pacific Northwest National Laboratory |
Cell type dependent radiation induced signaling and its effect on tissue regulation |
| Sykes, Pamela |
Flinders University and Medical Centre |
The pKZ1 transgene as a sensitive passive gene expression reporter for low dose radiation responses
Global methylation responses to low dose radiation exposure |
| Taylor, K |
McMaster University |
Low dose diagnostic radiation exposure and cancer risk in Trp53+/- mice |
| Tseng, Bertrand |
University of California |
Consequences of low dose irradiation in the CNS |
| Varnum, Susan |
Pacific Northwest National Laboratory |
Skin Tissue Response to Low Doses of Ionizing Radiation |
| Vijayakumar, Sangeetha |
New York University School of Medicine |
Origins and consequences of radiation–induced centrosome aberrations |
| Voy, Brynn |
Oak Ridge National Laboratory |
A Systems Genetics Approach to Low Dose Radiation |
| Wang, Minli |
USRA: Universities Space Research Association |
Space Radiation Can Enhance the TGFβ Induced
Epithelial–Mesenchymal Transition |
| Wanzer, M |
Northwestern University |
Use of X-ray fluorescence microscopy for archival tissue sample investigation |
| Waters, Katrina |
Pacific Northwest National Laboratory |
Data integration reveals key adaptive mechanisms in human 3D skin model after low dose exposure to ionizing radiation |
| Weber, Thomas |
Pacific Northwest National Laboratory |
Regulation of Annexin A2 by Ionizing Radiation in Human Skin Equivalent Culture: Does A Nuclear Annexin A2-Protein Kinase C Epsilon Complex Contribute To Reduced Cancer Risks At Low Dose Exposures? |
| Wilson, P.F. |
Brookhaven National Laboratory |
Hypersensitivity of human and rodent Fanconi anemia (FA) cells to bystander effect-induced DNA damage |
| Woloschak, Gayle |
Northwestern University |
Gene copy number changes in mitochondrial and nuclear genomes of archived samples |
| Wyrobek, Andrew |
Lawrence Berkeley National Laboratory |
Genetic, cell-type, and tissue variation in low-dose and adaptive radiation damage
responses as a means to understanding human cancer risks |
| Yang, Feng |
Pacific Northwest National Laboratory |
Identification of novel ionizing radiation signaling targets in reconstituted human skin |
| Yaswen, Paul |
Lawrence Berkeley National Laboratory |
Low dose radiation combines with the Src oncoprotein
to transform pre-malignant human breast cells |
| Young, Erik |
Columbia University |
Genetic Control of the Trigger for the G2/M Checkpoint |
| Zhang, Kai |
Lawrence Berkeley National Laboratory |
Inference of Causal Networks from Time-course Transcription Data in Response to a 2 Gy Challenge Dose of Ionizing Radiation with or without a 10 cGy Priming Dose |
