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David J. Grdina

Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL.

Currently Funded Projects

Prevention of Low Dose Radiation-Induced Genomic Instability with Cllinically Relevant Non-Protein Thiols and Vitamin E.

About This Project:

Inhibition of NFκB DNA Binding by Helenalin Abolishes the Induced Radioprotective Effect by Amifostine’s Active Metabolite WR1065 in Human Microvascular Endothelial Cells. Abstract. Description.

Technical Abstracts

2006 Workshop:
Prevention of Low Dose Radiation-Induced Genomic Instability with Clinically Relevant Non-Protein Thiols and Vitamin E.
Murley, J.S., Kataoka, Y., Morgan, W.F., and Grdina, D.J.

Adaptive and Reserve Adaptive Responses for Chromosomal Inversions in pKZ1 Mouse Prostrate: Hints on Mechanism
Day, T.K., Hooker, A.M, Zeng, G., Grdina, D.J., Scott, B.R., and Sykes, P.J.

2005 Workshop:
Inhibition of NFkB DNA Binding by Helenalin Abolishes the Induced Radioprotective Effect by Amifostine's Active Metabolite WR1065 in Human Microvascular Endothelial Cells
Murley, J.S., Kataoka, Y., and Grdina, D.J.

Publications

Murley, J.S., Nantajit, D., Baker, K.L., Kataoka, Y., Li, J.J., and Grdina, D.J. (2008) Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine. Radiation Research 169(5):495-505.

Murley, J.S., Kataoaka, Y., Baker, K.L., Diamond, A.M., Morgan, W.F., and Grdina, D.J. (2007) Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor α. Radiation Research 167(4):465-474.

Hooker, A.M., Day, T., Gridina, D.J., Bhat, M., and Sykes, P.J. (2006) Amifostine reduces chromosomal inversions pKZ1 spleen post X-irradiation. Environmental and Molecular Mutagenesis 47(6):429.

Kataoka, Y., Bindokas, V.P., Duggan, R.C., Murley, J.S., and Grdina, D.J. (2006) Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells. J. of Radiation Research 47(3-4):245-257.

Murley, J.S., Katakoa, Y., Baker, K.L., Diamond, A.M., Morgan, W.F., and Grdina, D.J. (2007) Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor α. Radiation Research 167:465-474.

Murley, J.S., Nantajit, D., Giometti, C., Diamond, A., Kataoka, Y., and Grdina, D.J. (2006) A persisitent thiol-induced MnSOD-mediated delayed cytoprotective effect in human microvascular endothelial cells (HMEC). Environmental and Molecular Mutagenesis 47(6):466.

Grdina, D.J., Murley, J.S., Kataoka, Y., Zhou, D., and Seed, T.M. (2005) Radiotherapeutic interactions. Extended Abstracts. Radiation Research 163:704-705.

Grdina, D.J., Murley, J.S., Kataoka, Y., and Epperly, W. (2002) Relationships between cytoprotection and mutation prevention by WR-1065. Military Medicine 167 Suppl:51-53.

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