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Low Dose Radiation Research Program

Draft of Low Dose Program History 1998-2008 Available for Review and Comment

The history of the first decade of DOE Low Dose Radiation Research Program has been written by former DOE Low Dose Program Chief Scientist Dr. Antone (Tony) Brooks. A review draft of the book is available here in PDF form. Comments, revisions, and questions should go directly to Dr. Brooks at tbrooks@tricity.wsu.edu.

Low Dose Radiation-Induced Epigenetic Alterations Found in Agouti Mouse Model

Low Dose Radiation-Induced Epigenetic Alterations Found in Agouti Mouse Model

In a paper published in The FASEB Journal, Low Dose researchers from Duke University, University of Wisconsin-Madison, and the University of Michigan showed that exposures to low-doses of ionizing radiation (LDIR) in utero can alter the epigenetic response of the agouti viable yellow (Avy) mouse. This alteration resulted in increased DNA methylation, which plays an important role for epigenetic gene regulation in development and disease. It also increased the frequency of offspring showing the agouti-brown coat color.
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Zia ZhangJie Zhang

Translationally Controlled Tumor Protein Induced by Low-Dose Radiation Protects Against DNA Damage

In research published online in the Proceedings of the National Academies of Science, scientists at the University of Medicine and Dentistry of New Jersey and the Fourth Military Medical University in the People's Republic of China described an important role of a multifunctional protein in response to low dose radiation-induced DNA damage.
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Irradiated Tissue Archives Featured in Nature

A recent news article in Nature highlights work being done on archived data and materials from radiation studies performed between 1952 and 1992, and its relevance to questions being addressed by DOE's Low Dose Radiation Research Program. The article, "Radiation risks: Raiders of the lost archive," features quotes from Low Dose Program researcher Dr. Gayle Woloschak, a radiation biologist at Northwestern University in Chicago, Illinois, whose laboratory hosts radiobiology archives containing data and tissues from radiobiology mega studies conducted in the second half of the 20th century.

Human Skin Model Shows Signaling Pathway Effects from Low Dose Exposure

In studies on a human skin tissue model, researchers at Pacific Northwest National Laboratory used a systems biology approach to show that an ionizing radiation dose mimicking that received during a CT scan is sufficient to alter genes in two cell layers. The epidermis is the outer skin layer, and the dermis is beneath it.
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Proteomics Identifies Targets of Ionizing Radiation in a Human Skin Model

How better to find out what effect ionizing radiation has on human skin than by using the real thing? Researchers at Pacific Northwest National Laboratory did that by performing a quantitative mass spectrometry study on a reconstituted human skin tissue model to identify areas affected by ionizing radiation exposure.
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Hlatky to Receive Leadership Award from International Society

Dr. Lynn Hlatky, DOE Low Dose researcher and Director of the Center of Cancer Systems Biology at St. Elizabeth's Medical Center/Tufts University School of Medicine in Boston, MA, has been selected by the International Dose-Response Society as this year's recipient of the Outstanding Leadership Award in the field of dose response. This annual award of excellence recognizes a scientist who has "contributed to a deeper understanding of the relationships between dose and response."

Created in 2005, the International Dose-Response Society is dedicated to the study of dose-response in the low dose zone. Dr. Hlatky's award will be presented at the upcoming 11th Annual International Conference: "Dose-Response: Implications for Toxicology, Medicine, and Risk Assessment" in April 2012 in Amherst, MA.

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